CAMRD Project List
 
 CAMRD Project Number Principal Investigator Project Title  Renewal Date
 260 Michael J. Alexander, MD Evaluation of Neurovascular Microstent Grafts  
 261 Michael D. De Bellis, MD A Research Study on Life Events and Childhood Brain Development  9/2008
 262 Miguel A. Al. Nicolelis, MD.,PHD  MRI-guided Sterotactic Localization for Electrode Placement in Non-human Primates  
 263  Kimberly Blackwell, MD  Optimized Thrombin Inhibition (Refludan, Lepirudin (rdna Hirudin) with and without weekly Docetaxel in Metastic Breast Cancer Patients  
 264  Lin Sikich, MD  Study of Human Brain in Youth with MRI and Spectroscopy
 265 Herbert Hurwitz, MD A Phase I, Open-Label, Multiple-Dose, Dose Escalation Study of GW786034
 266  Frank Dunphy, MD  Open Label, Phase I, Dose Escalation Study of Intralesional Injection of Tetra-O-Methyl Nordihydroguaiaretic Acid (M4N) in Patients with Refactory Malignant Tumors of the Head and Neck  
 267 James Provenzale, MD Evaluation of Multiple Sclerosis Using Tensor DW Imaging and Multivoxel Proton MR Spectroscopy
 268 K. Ranga R. Krishnan, MD Location of White Matter Hyperintensities and Alterations in White Matter Tracts in Late Onset Depression (Duke Silvio Conte Center)  12/2008
271 Michael D. De Bellis, MD Factors Influencing Childhood Brain Development
272
Michael D. De Bellis, MD Adolescent Alcohol Abuse, PTSD and Hippocampal Development
273 Dan Barboriak, MD Perfusion and Diffusion Tensor MR imaging of the Surgical Margin in Primary Cerebral Glioma
276 Barrie Hurwitz, MD A Randomized, Rater-Blinded, Multicenter, Parallel-Group Study Comparing the Efficacy and Safety of Betaseron 250mcg Subcutaneously Every Other Day With Avonex 30mcg Intramuscularly Once A Week In Relapsing-remitting Multiple Sclerosis Patients Previously Treated with Avonex. (ABOVE)
277 Laura Schanberg,MD A Multicenter, Randomized, Double-Blind Placebo-Controlled Study to test the Safety and Efficacy of Lipitor (atorvastatin) in Reducing the Progression of Carotid IMT in Early Childhood SLE. The Atherosclerosis Prevention in Pediatric Lupus Erythematosus (APPLE) Study 2/2009
278 John Thomas, MD et. al. To assess the ability of Secretin stimulated MRCP to predict outcome in patients with pancreas divisum and pancreatitis, who will undergo minor papilla sphincterotomy.
279 John Sampson, MD, Ph.D Pilot Imaging Study to Assess the Distribution of IL 13-PE38QQR Cytotoxin Infusions in Patients with Recurrent, Resectable, Supratentorial Malignant Glioma (IL-13PEI-105-R02 study).
280 Nancy Major, MD Optimizing 3 Tesla MR Evaluation of the Acetabular Labrum
281 H. Cecil Charles, Ph.D A Multi-Center, Double-blind, Placebo-controlled, Randomized, Parallel Group Evaluation of the Efficacy of a Flexible Dose of Lamotrigine versus Placebo As Add-On Therapy in Schizophrenia: Magnetic Resonance Spectroscopy (MRS) Substudy.
282 Elmar M. Merkle, MD Breath-hold MRCP at 3T using a new dedicated body receiving coil - Comparison with state of the art MRCP at 1.5T.
283 Priya Kishnani, MD

H.Cecil Charles, Ph.D

A Study of the progression of swallowing and breathing and the use of magnetic resonance spectroscopy to measure muscle glycogen content in children with Pompe disease
284 H. Cecil Charles, Ph.D Optimization and Cross-Validation of MRI Sequences for Measuring Cartilage Volume
285 Elmar Merkle, MD Parallel Imaging Acceleration of the VIBE Acquisition Technique in Hepatic MR Angiography: Potential Simultaneous Increase in Temporal Resolution and Contrast with Novel Gadolinium Regime
286 John Sampson, MD, Ph.D Phase III Randomized Evaluation of Convection Enhanced Delivery of IL13-PE38QQR Compared to Gliadel® Wafer With Survival Endpoint in Glioblastoma Muliforme Patients At First Recurrence (PRECISE - IL13PE-301)
287 Elmar Merkle, MD Comprehensive MR Approach in the Evaluation of Living Related Liver Donors: Comparison of Ultra High Field MRI at 3 Tesla with Contrast-Enhanced CT and ERCP
288 Daniel George, MD A phase II open-label study of oral, continuous, once daily PTK787/ZK in subjects with VHL and HB
289 Barrie Hurwitz, MD An international, randomized, multicenter, phase III study in patients with relapsing-remitting multiple sclerosis comparing over a treatment period of 104 weeks:

1. Double-blinded the safety, tolerability, and efficacy of Betaseron®/Betaferon® 250 µg (8 MIU) and Betaseron ®/Betaferon® 500µg (16 MIU), both given subcutaneously every other day, and

2. Rater-blinded the safety, tolerability, and efficacy of Betaseron®/Betaferon® 250 µg (8 MIU) s.c. every other day with Copaxone® 20 mg. s.c. once daily

BEYOND = Betaseron®/Betaferon® Efficacy Yielding Outcomes of a New Dose

290 Victoria Seewaldt, MD et. al. Does loss of retinoid receptor function promote breast cancer (RPFNA). 2/2009
291 Lynne M. Hurwitz, MD Optimizing cardiac MR imaging on a 3T MRI system 11/2007
292 John Sampson, MD, Ph.D Phase I study of convection enhanced delivery (CED) of IL13-PE38QQR infusion after resection followed by radiation therapy with or without temozolomide in patients with newly diagnosed supratentorial malignant glioma
293 Virginia Byers Kraus, MD, Ph.D

H. Cecil Charles, Ph.D

A Longitudinal Study of Osteoarthritis (OA) Disease Progression Measured by MRI, dGEMRIC, and Radiography.
294 John L. Beyer, MD Bipolar Disorder in Late Life 5/2009
295 Elmar Merkle, MD Evaluation of the Dielectric Cushion in Ultra High Field MRI of the Abdomen.
296 David Steffens, MD; James MacFall, PhD Biomedical Informatics Research Network (BIRN) Reproducibility Study 1/2009
297 David A. Reardon, MD Dynamic Contrast Enhanced (DCE) and Diffusion Weighted Imaging (DWI) MRI in the Brain (2103)
298 David A. Reardon, MD Dynamic Contrast Enhanced (DCE) and Diffusion Weighted Imaging (DWI) MRI in the Brain (2106)
299 P. Murali Doraiswamy, MD Alzheimer's Disease Neuroimaging Initiative (ADNI) 9/2008
300 Barrie Hurwitz, MD A phase III, randomized, double-blind, three-arm, placebo-controlled, multi-center study to evaluate the safety and efficacy of oral cladribine in subjects with relapsing-remitting multiple sclerosis (RRMS) (Serono Protocol No. 25643) 3/2009
301 Elmar Merkle, MD Phase 2 Study of CP-868,596 in Combination with Docetaxel and of Docetaxel alone in Patients with Stage IIIB or IV Non-Small Cell Lung Cancer, Preceded by a Phase IB Dose-Finding, safety and Tolerability study of the Combination in All Solid Tumor Types
302 Elmar Merkle, MD; Herbert Hurwitz, MD Phase I Study of Every Other Week Anti-Vascular Endothelial Growth Factor Receptor 2 (VEGFR-2) Monoclonal Antibody IMC-1121B in Patients with Advanced Solid Tumors Who Have Not Responded to Standard Therapy 5/2009
303 H. Cecil Charles, PhD; Virginia Kraus, PhD Development and Validation of glycosaminoglycan ("GAG") depletion mapping in osteoarthritis using delayed contrast enhanced MRI
304 Mark Skeen, MD Multicenter, Randomized, Double-Blind, Placebo-controlled Study of Subcutaneous Toxaxin in Subjects with Clinically Isolated Syndrome or Relapsing-Remitting Multiple Sclerosis
305 William E. Garrett, Jr., MD, PhD A Pilot Research Study On The Effects Of Intermittent Compression In Post-Surgical Knee Effusion
306 Michael Platt,PhD Cortical and Subcortical Mechanisms Of Eye Movement Control 7/2008
307 James A. Nunley, MD, Nancy Major, MD Infrapatellar Fat Pad: MRI Analysis In Correlation With Osteoarthritis of Knee Joint
308 Nancy Major, MD MR Imaging of the Pelvis: Findings in Asymptomatic Collegiate Soccer Players 12/2008
309 Louis DeFrate, PhD Pig Knee Pilot Sudy for Meniscus Studies
310 Ricki F. Goldstein, MD Neuroimaging and Neurodevelopmental Outcome: A Secondary to the Surfactant Positive Airway Pressure and Pulse Oximetry Trial (SUPPORT) 12/2008
311 Elmar Merkle, MD Diffusion Weighted Imaging of the Pancreas: Preliminary Experience in Healthy Volunteers
312 Jennifer M. Groh,PhD Anatomical Scanning of Rhesus Macaque Brain 5/2009
313 Louis DeFrate, PhD In Vivo Cartilage Contact Patterns in Patients with Meniscus Injury and Repair 3/2009
314 Lee W. Jones, PhD Changes in Functional Status Across Therapy for Primary Glioma 2/2009
315 Lisa M. Ho, MD Effects of Iodinated Contrast Media on Signal Intensity During Abdominal MR Imaging 4/2009
316

David Reardon, MD

Evaluation of Patients with Malignant Glioma Treated With Anti-Angiogenic Therapy Using Complimentary Magnetic Resonance Imaging Approaches 5/2009
317 Louis DeFrate, PhD In-vivo kinematics and contact of the ankle joint in patients with lateral ankle instability 4/2008
318 Lee Cothran, MD Patellofemoral and tibiofemoral joint kinematics 6/2008
319 Courtney Coursey, MD; Rendon Nelson, MD Pilot investigation of rate of injection and quantity of gadolinium injected using a phantom: What is the optimal injection rate and quantity? 7/2008
320 Warren Taylor, MD Vascular Depression: Longitudinal Changes 7/2008
321 Charles Spritzer, MD Alteration of cartilage contact points after ACL reconstruction 8/2008
322 Charles Spritzer, MD Changes in Femoral/Tibial Cartilage Contact Points After Anterior Cruciate Ligament Reconstruction 10/2008
323 William E. Kraus,MD (Co-investigators: R. Nelson, MD, Brian Soher, PhD, Cecil Charles, PhD) Magnetic Resonance Imaging (MRI) Sub-Study (STRRIDE) 10/2008
324 Kimberly Blackwell, MD Phase II Efficacy and Tolerability Study of RTA 744 in Breast Cancer Patients with Progression of Previously Irradiated Brain Metastases 10/2008
325 Priya Kishnani, MD A Multicenter Open-Label Study of Gene-Activated Human Glucocerebrosidase (GA-GCB) Enzyme Replacement Therapy in Patients with Type 1 Gaucher Disease Previously Treated with Imiglucerase 12/2008
326 Priya Kishnani, MD A Multicenter, Randomized, Double-Blind, Parallel-Group Study of Gene-Activated® Human Glucocerebrosidase (GA-GCB) Enzyme Replacement Therapy Compared with Imiglucerase in Patients with Type I Gaucher Disease 12/2008
327 Nancy Major,MD Longitudinal 3-D 3T SPACE MRI and Articular Cartilage Lesions of the Knee 12/2008
328 Warren D. Taylor, MD Genes and Alterations in Brain Structure and Function in Depression 2/2009
329 Elmar M. Merkle, MD; Brian Soher, PhD Diagnosis and grading of liver fibrosis in a rat model: Using in vivo water-fat content discrimination and time-resolved diffusion-weighted MR imaging after fructose stimulation 2/2009
330 Sujata Ghate, MD MRI Artifact Evaluation of Marking Clips in a Breast Phantom 5/2009